Efficacy of cocoa pod extract as antiwrinkle gel on human skin surface.
Identifieur interne : 000C51 ( Main/Exploration ); précédent : 000C50; suivant : 000C52Efficacy of cocoa pod extract as antiwrinkle gel on human skin surface.
Auteurs : Azila Abdul Karim [Malaisie] ; Azrina Azlan [Malaisie] ; Amin Ismail [Malaisie] ; Puziah Hashim [Malaisie] ; Siti Salwa Abd Gani [Malaisie] ; Badrul Hisyam Zainudin [Malaisie] ; Nur Azilah Abdullah [Malaisie]Source :
- Journal of cosmetic dermatology [ 1473-2165 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Cacaoyer (MeSH), Cellules cultivées (MeSH), Extraits de plantes (composition chimique), Extraits de plantes (pharmacologie), Femelle (MeSH), Fibroblastes (MeSH), Fruit (MeSH), Gels (MeSH), Humains (MeSH), Peau (effets des médicaments et des substances chimiques), Phytothérapie (MeSH), Survie cellulaire (effets des médicaments et des substances chimiques), Vieillissement de la peau (effets des médicaments et des substances chimiques).
- MESH :
- composition chimique : Extraits de plantes.
- effets des médicaments et des substances chimiques : Peau, Survie cellulaire, Vieillissement de la peau.
- pharmacologie : Extraits de plantes.
- Adulte, Adulte d'âge moyen, Cacaoyer, Cellules cultivées, Femelle, Fibroblastes, Fruit, Gels, Humains, Phytothérapie.
English descriptors
- KwdEn :
- Adult (MeSH), Cacao (MeSH), Cell Survival (drug effects), Cells, Cultured (MeSH), Female (MeSH), Fibroblasts (MeSH), Fruit (MeSH), Gels (MeSH), Humans (MeSH), Middle Aged (MeSH), Phytotherapy (MeSH), Plant Extracts (chemistry), Plant Extracts (pharmacology), Skin (drug effects), Skin Aging (drug effects).
- MESH :
- chemical , chemistry : Plant Extracts.
- chemical , pharmacology : Plant Extracts.
- chemical : Gels.
- drug effects : Cell Survival, Skin, Skin Aging.
- Adult, Cacao, Cells, Cultured, Female, Fibroblasts, Fruit, Humans, Middle Aged, Phytotherapy.
Abstract
OBJECTIVE
Cocoa pods are abundant waste materials of cocoa plantation, which are usually discarded onto plantation floors. However, due to poor plantation management, the discarded cocoa pods can create suitable breeding ground for Phytophthora palmivora, which is regarded as the causal agent of the black pod disease. On the other hand, cocoa pods potentially contain antioxidant compounds. Antioxidant compounds are related to the protection of skin from wrinkles and can be used as functional cosmetic ingredients. Therefore, in this study, cocoa pods were extracted and to be used as active ingredients for antiwrinkles.
METHODS
The active compounds in cocoa pod extracts (CPE) were screened using liquid chromatography-mass spectrometry (LC-MS). Fibroblast cells were used to determine the effective concentration of CPE to maintain the viability for at least 50% of the cells (EC50 ). The gel was tested by 12 panelists to determine the efficacy of CPE in gel form using Visioscan to reduce skin wrinkles and improve skin condition.
RESULTS
CPE was detected to contain malic acid, procyanidin B1, rosmarinic acid, procyanidin C1, apigenin, and ellagic acid, all of which may contribute to functional cosmetic properties of CPE. The EC50 value of cocoa pod extracts was used to calculate the amount of CPE to be incorporated into gel so that the formulated product could reach an effective concentration of extract while being nonintoxicant to the skin cell. The results showed that CPE is potential ingredient to reduce wrinkles. Skin wrinkles reduced at 6.38 ± 1.23% with the application of the CPE gel within 3 weeks and significantly improved further (12.39 ± 1.59%) after 5 weeks. The skin hydration increased (3.181 ± 1.06%) after 3 weeks of the CPE gel application.
CONCLUSION
Flavonoid compounds in CPE contributed to the functional cosmetic properties of CPE. The CPE which is nontoxic to skin cells help to reduce wrinkles on skin after 3 weeks of application. CPE can be used as the active ingredients in antiwrinkle products, and prolonged application may result in significant visual changes to the naked eyes.
DOI: 10.1111/jocd.12218
PubMed: 27041391
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy of cocoa pod extract as antiwrinkle gel on human skin surface.</title><author><name sortKey="Abdul Karim, Azila" sort="Abdul Karim, Azila" uniqKey="Abdul Karim A" first="Azila" last="Abdul Karim">Azila Abdul Karim</name><affiliation wicri:level="1"><nlm:affiliation>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan</wicri:regionArea><wicri:noRegion>Negeri Sembilan</wicri:noRegion></affiliation></author><author><name sortKey="Azlan, Azrina" sort="Azlan, Azrina" uniqKey="Azlan A" first="Azrina" last="Azlan">Azrina Azlan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Research Centre of Excellence, Nutrition and Non-communicable Disease, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Research Centre of Excellence, Nutrition and Non-communicable Disease, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Ismail, Amin" sort="Ismail, Amin" uniqKey="Ismail A" first="Amin" last="Ismail">Amin Ismail</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Hashim, Puziah" sort="Hashim, Puziah" uniqKey="Hashim P" first="Puziah" last="Hashim">Puziah Hashim</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Abd Gani, Siti Salwa" sort="Abd Gani, Siti Salwa" uniqKey="Abd Gani S" first="Siti Salwa" last="Abd Gani">Siti Salwa Abd Gani</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Zainudin, Badrul Hisyam" sort="Zainudin, Badrul Hisyam" uniqKey="Zainudin B" first="Badrul Hisyam" last="Zainudin">Badrul Hisyam Zainudin</name><affiliation wicri:level="1"><nlm:affiliation>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan</wicri:regionArea><wicri:noRegion>Negeri Sembilan</wicri:noRegion></affiliation></author><author><name sortKey="Abdullah, Nur Azilah" sort="Abdullah, Nur Azilah" uniqKey="Abdullah N" first="Nur Azilah" last="Abdullah">Nur Azilah Abdullah</name><affiliation wicri:level="1"><nlm:affiliation>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan</wicri:regionArea><wicri:noRegion>Negeri Sembilan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27041391</idno><idno type="pmid">27041391</idno><idno type="doi">10.1111/jocd.12218</idno><idno type="wicri:Area/Main/Corpus">000C31</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C31</idno><idno type="wicri:Area/Main/Curation">000C31</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000C31</idno><idno type="wicri:Area/Main/Exploration">000C31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy of cocoa pod extract as antiwrinkle gel on human skin surface.</title><author><name sortKey="Abdul Karim, Azila" sort="Abdul Karim, Azila" uniqKey="Abdul Karim A" first="Azila" last="Abdul Karim">Azila Abdul Karim</name><affiliation wicri:level="1"><nlm:affiliation>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan</wicri:regionArea><wicri:noRegion>Negeri Sembilan</wicri:noRegion></affiliation></author><author><name sortKey="Azlan, Azrina" sort="Azlan, Azrina" uniqKey="Azlan A" first="Azrina" last="Azlan">Azrina Azlan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Research Centre of Excellence, Nutrition and Non-communicable Disease, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Research Centre of Excellence, Nutrition and Non-communicable Disease, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Ismail, Amin" sort="Ismail, Amin" uniqKey="Ismail A" first="Amin" last="Ismail">Amin Ismail</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Hashim, Puziah" sort="Hashim, Puziah" uniqKey="Hashim P" first="Puziah" last="Hashim">Puziah Hashim</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Abd Gani, Siti Salwa" sort="Abd Gani, Siti Salwa" uniqKey="Abd Gani S" first="Siti Salwa" last="Abd Gani">Siti Salwa Abd Gani</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Zainudin, Badrul Hisyam" sort="Zainudin, Badrul Hisyam" uniqKey="Zainudin B" first="Badrul Hisyam" last="Zainudin">Badrul Hisyam Zainudin</name><affiliation wicri:level="1"><nlm:affiliation>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan</wicri:regionArea><wicri:noRegion>Negeri Sembilan</wicri:noRegion></affiliation></author><author><name sortKey="Abdullah, Nur Azilah" sort="Abdullah, Nur Azilah" uniqKey="Abdullah N" first="Nur Azilah" last="Abdullah">Nur Azilah Abdullah</name><affiliation wicri:level="1"><nlm:affiliation>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan</wicri:regionArea><wicri:noRegion>Negeri Sembilan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of cosmetic dermatology</title><idno type="eISSN">1473-2165</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Cacao (MeSH)</term><term>Cell Survival (drug effects)</term><term>Cells, Cultured (MeSH)</term><term>Female (MeSH)</term><term>Fibroblasts (MeSH)</term><term>Fruit (MeSH)</term><term>Gels (MeSH)</term><term>Humans (MeSH)</term><term>Middle Aged (MeSH)</term><term>Phytotherapy (MeSH)</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Skin (drug effects)</term><term>Skin Aging (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Cacaoyer (MeSH)</term><term>Cellules cultivées (MeSH)</term><term>Extraits de plantes (composition chimique)</term><term>Extraits de plantes (pharmacologie)</term><term>Femelle (MeSH)</term><term>Fibroblastes (MeSH)</term><term>Fruit (MeSH)</term><term>Gels (MeSH)</term><term>Humains (MeSH)</term><term>Peau (effets des médicaments et des substances chimiques)</term><term>Phytothérapie (MeSH)</term><term>Survie cellulaire (effets des médicaments et des substances chimiques)</term><term>Vieillissement de la peau (effets des médicaments et des substances chimiques)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Gels</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Skin</term><term>Skin Aging</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Peau</term><term>Survie cellulaire</term><term>Vieillissement de la peau</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Extraits de plantes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cacao</term><term>Cells, Cultured</term><term>Female</term><term>Fibroblasts</term><term>Fruit</term><term>Humans</term><term>Middle Aged</term><term>Phytotherapy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cacaoyer</term><term>Cellules cultivées</term><term>Femelle</term><term>Fibroblastes</term><term>Fruit</term><term>Gels</term><term>Humains</term><term>Phytothérapie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>Cocoa pods are abundant waste materials of cocoa plantation, which are usually discarded onto plantation floors. However, due to poor plantation management, the discarded cocoa pods can create suitable breeding ground for Phytophthora palmivora, which is regarded as the causal agent of the black pod disease. On the other hand, cocoa pods potentially contain antioxidant compounds. Antioxidant compounds are related to the protection of skin from wrinkles and can be used as functional cosmetic ingredients. Therefore, in this study, cocoa pods were extracted and to be used as active ingredients for antiwrinkles.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>The active compounds in cocoa pod extracts (CPE) were screened using liquid chromatography-mass spectrometry (LC-MS). Fibroblast cells were used to determine the effective concentration of CPE to maintain the viability for at least 50% of the cells (EC50 ). The gel was tested by 12 panelists to determine the efficacy of CPE in gel form using Visioscan to reduce skin wrinkles and improve skin condition.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>CPE was detected to contain malic acid, procyanidin B1, rosmarinic acid, procyanidin C1, apigenin, and ellagic acid, all of which may contribute to functional cosmetic properties of CPE. The EC50 value of cocoa pod extracts was used to calculate the amount of CPE to be incorporated into gel so that the formulated product could reach an effective concentration of extract while being nonintoxicant to the skin cell. The results showed that CPE is potential ingredient to reduce wrinkles. Skin wrinkles reduced at 6.38 ± 1.23% with the application of the CPE gel within 3 weeks and significantly improved further (12.39 ± 1.59%) after 5 weeks. The skin hydration increased (3.181 ± 1.06%) after 3 weeks of the CPE gel application.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Flavonoid compounds in CPE contributed to the functional cosmetic properties of CPE. The CPE which is nontoxic to skin cells help to reduce wrinkles on skin after 3 weeks of application. CPE can be used as the active ingredients in antiwrinkle products, and prolonged application may result in significant visual changes to the naked eyes.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27041391</PMID><DateCompleted><Year>2017</Year><Month>07</Month><Day>07</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1473-2165</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of cosmetic dermatology</Title><ISOAbbreviation>J Cosmet Dermatol</ISOAbbreviation></Journal><ArticleTitle>Efficacy of cocoa pod extract as antiwrinkle gel on human skin surface.</ArticleTitle><Pagination><MedlinePgn>283-95</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jocd.12218</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Cocoa pods are abundant waste materials of cocoa plantation, which are usually discarded onto plantation floors. However, due to poor plantation management, the discarded cocoa pods can create suitable breeding ground for Phytophthora palmivora, which is regarded as the causal agent of the black pod disease. On the other hand, cocoa pods potentially contain antioxidant compounds. Antioxidant compounds are related to the protection of skin from wrinkles and can be used as functional cosmetic ingredients. Therefore, in this study, cocoa pods were extracted and to be used as active ingredients for antiwrinkles.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The active compounds in cocoa pod extracts (CPE) were screened using liquid chromatography-mass spectrometry (LC-MS). Fibroblast cells were used to determine the effective concentration of CPE to maintain the viability for at least 50% of the cells (EC50 ). The gel was tested by 12 panelists to determine the efficacy of CPE in gel form using Visioscan to reduce skin wrinkles and improve skin condition.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">CPE was detected to contain malic acid, procyanidin B1, rosmarinic acid, procyanidin C1, apigenin, and ellagic acid, all of which may contribute to functional cosmetic properties of CPE. The EC50 value of cocoa pod extracts was used to calculate the amount of CPE to be incorporated into gel so that the formulated product could reach an effective concentration of extract while being nonintoxicant to the skin cell. The results showed that CPE is potential ingredient to reduce wrinkles. Skin wrinkles reduced at 6.38 ± 1.23% with the application of the CPE gel within 3 weeks and significantly improved further (12.39 ± 1.59%) after 5 weeks. The skin hydration increased (3.181 ± 1.06%) after 3 weeks of the CPE gel application.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Flavonoid compounds in CPE contributed to the functional cosmetic properties of CPE. The CPE which is nontoxic to skin cells help to reduce wrinkles on skin after 3 weeks of application. CPE can be used as the active ingredients in antiwrinkle products, and prolonged application may result in significant visual changes to the naked eyes.</AbstractText><CopyrightInformation>© 2016 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Abdul Karim</LastName><ForeName>Azila</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azlan</LastName><ForeName>Azrina</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research Centre of Excellence, Nutrition and Non-communicable Disease, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ismail</LastName><ForeName>Amin</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hashim</LastName><ForeName>Puziah</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abd Gani</LastName><ForeName>Siti Salwa</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zainudin</LastName><ForeName>Badrul Hisyam</ForeName><Initials>BH</Initials><AffiliationInfo><Affiliation>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abdullah</LastName><ForeName>Nur Azilah</ForeName><Initials>NA</Initials><AffiliationInfo><Affiliation>Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan, Malaysia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Cosmet Dermatol</MedlineTA><NlmUniqueID>101130964</NlmUniqueID><ISSNLinking>1473-2130</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005782">Gels</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002099" MajorTopicYN="Y">Cacao</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005347" MajorTopicYN="N">Fibroblasts</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005782" MajorTopicYN="N">Gels</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008517" MajorTopicYN="Y">Phytotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015595" MajorTopicYN="N">Skin Aging</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">antiwrinkles</Keyword><Keyword MajorTopicYN="N">cell culture</Keyword><Keyword MajorTopicYN="N">cocoa pod extracts</Keyword><Keyword MajorTopicYN="N">efficacy</Keyword><Keyword MajorTopicYN="N">formulation</Keyword><Keyword MajorTopicYN="N">functional cosmetics</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>03</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27041391</ArticleId><ArticleId IdType="doi">10.1111/jocd.12218</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Malaisie</li></country></list><tree><country name="Malaisie"><noRegion><name sortKey="Abdul Karim, Azila" sort="Abdul Karim, Azila" uniqKey="Abdul Karim A" first="Azila" last="Abdul Karim">Azila Abdul Karim</name></noRegion><name sortKey="Abd Gani, Siti Salwa" sort="Abd Gani, Siti Salwa" uniqKey="Abd Gani S" first="Siti Salwa" last="Abd Gani">Siti Salwa Abd Gani</name><name sortKey="Abdullah, Nur Azilah" sort="Abdullah, Nur Azilah" uniqKey="Abdullah N" first="Nur Azilah" last="Abdullah">Nur Azilah Abdullah</name><name sortKey="Azlan, Azrina" sort="Azlan, Azrina" uniqKey="Azlan A" first="Azrina" last="Azlan">Azrina Azlan</name><name sortKey="Azlan, Azrina" sort="Azlan, Azrina" uniqKey="Azlan A" first="Azrina" last="Azlan">Azrina Azlan</name><name sortKey="Azlan, Azrina" sort="Azlan, Azrina" uniqKey="Azlan A" first="Azrina" last="Azlan">Azrina Azlan</name><name sortKey="Hashim, Puziah" sort="Hashim, Puziah" uniqKey="Hashim P" first="Puziah" last="Hashim">Puziah Hashim</name><name sortKey="Ismail, Amin" sort="Ismail, Amin" uniqKey="Ismail A" first="Amin" last="Ismail">Amin Ismail</name><name sortKey="Zainudin, Badrul Hisyam" sort="Zainudin, Badrul Hisyam" uniqKey="Zainudin B" first="Badrul Hisyam" last="Zainudin">Badrul Hisyam Zainudin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PhytophthoraV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C51 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C51 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PhytophthoraV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27041391
|texte= Efficacy of cocoa pod extract as antiwrinkle gel on human skin surface.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27041391" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PhytophthoraV1
| This area was generated with Dilib version V0.6.38. |  |